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目的探讨Ⅰ期子宫内膜癌外科治疗后放射治疗的生存状况。方法选取2010年3月至2014年2月间连云港市东方医院收治的进行外科治疗后放射治疗的65例Ⅰ期子宫内膜癌患者,分析患者治疗后无瘤生存率、复发率、转移率和总生存率。结果Ⅰ期子宫内膜癌患者经外科治疗后放射治疗的3年总生存率为89.2%,无瘤生存率为87.6%。5年总生存率、无瘤生存率分别为80.0%、73.8%。局部复发3例(4.6%),远处转移4例(6.1%)。急性放射性肠炎11例(16.9%),急性放射性膀胱炎7例(10.7%),肠穿孔1例(1.5%),肠梗阻2例(3.1%),便血4例(6.1%)。不同分化程度、有无肌层浸润及淋巴结是否受累与Ⅰ期子宫内膜癌外科治疗后放射治疗患者5年生存率具有一定相关性,差异均有统计学意义(均P<0.05)。结论Ⅰ期子宫内膜癌患者经外科治疗后放射治疗的不良反应发生率低,不易发生局部复发及远处转移,生存期长。
Objective To investigate the survival of stage Ⅰ endometrial cancer after surgical treatment of radiation therapy. Methods A total of 65 patients with stage Ⅰ endometrial cancer undergoing radiotherapy after surgery were selected from March 2010 to February 2014 in Dongfang Hospital of Lianyungang. The patients’ post-treatment tumor-free survival rate, recurrence rate and metastasis rate The overall survival rate. Results The 3-year overall survival rate of patients with stage Ⅰ endometrial cancer after radiotherapy was 89.2% and the tumor-free survival rate was 87.6%. 5-year overall survival rate, tumor-free survival rates were 80.0%, 73.8%. Local recurrence in 3 cases (4.6%), distant metastasis in 4 cases (6.1%). Acute radiation enteritis in 11 cases (16.9%), acute radiation cystitis in 7 cases (10.7%), intestinal perforation in 1 case (1.5%), intestinal obstruction in 2 cases (3.1%) and blood in the stool in 4 cases (6.1%). Different degrees of differentiation, with or without myometrial invasion and lymph node involvement and stage Ⅰ endometrial cancer surgery after radiotherapy patients with 5-year survival rate has a certain relevance, the differences were statistically significant (P <0.05). Conclusions The incidence of adverse reactions in patients with stage Ⅰ endometrial cancer treated with radiotherapy after radiotherapy is low, local recurrence and distant metastasis are unlikely to occur, and the survival period is long.