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对41例初诊住院急性早幼粒细胞白血病(APL)患者进行了一般资料、形态学(M)、免疫学(I)、细胞遗传学(C)、DIC筛选检查等生物学特征的分析,并探讨了他们与临床的关系。结果显示:APL患者小于50岁者发病率高于大于50岁者,且小于50岁者疗效好于大于50岁者(P<0.05);初诊时白细胞数量、形态学分型(M3a,M3b)与疗效之间无显著差异;APL患者免疫表型主要以CD_(13)、CD_(33)阳性,CD_(34)阴性为主;细胞遗传学分析发现有t(15;17)改变者高于无此改变者;DIC阴性者疗效明显好于DIC阳性者(P<0.001);白细胞数(WBC)>25×10~9/L者DIC发病率较高,有DIC者病死率较高。
The general characteristics, morphological (M), immunological (I), cytogenetics (C), DIC screening, and other biological characteristics of 41 newly diagnosed patients with acute promyelocytic leukemia (APL) were analyzed. Discussed their relationship with the clinic. The results showed that the incidence of APL patients less than 50 years old was higher than that of patients older than 50 years old, and those less than 50 years old were better than those older than 50 years old (P<0.05). The number of white blood cells and morphological type (M3a, M3b) were different at the time of initial diagnosis. There was no significant difference in efficacy; the immunophenotypes of APL were mainly CD_(13), CD_(33) positive, and CD_(34) negative; cytogenetic analysis revealed that t(15;17) changes were higher than none. This change; DIC negative was significantly better than DIC positive (P <0.001); WBC> 25 × 10 ~ 9 / L were higher incidence of DIC, DIC had a higher mortality.