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日本Ｓｈｉｎｙａｋｕ公司的科学家合成了一系列(1,3)硫氮杂环(3,2ａ)喹诺酮3羧酸及其酯类化合物,并评价它们的抗菌活性。发现化合物ｐｒｕｌｉｆｌｏｘａｃｉｎ(ＮＭ441)具有令人满意的药动学性质,动物实验的口服活性优于环丙沙星。抗菌活性 ｐｒｕｌｉｆｌｏｘａｃｉｎ是氟
Japanese scientists Shinyaku scientists synthesized a series of (1,3) thiazacyclic (3,2a) quinolone 3 carboxylic acids and their esters, and evaluated their antibacterial activity. The compound prulifloxacin (NM441) was found to possess satisfactory pharmacokinetic properties and the oral activity of animal experiments was superior to that of ciprofloxacin. Antibacterial activity prulifloxacin is fluorine