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临床研究难以获得心肌组织,本研究采用~3H-DHA放射性配基结合法对4例风心,4例先心手术共8例病人,年龄30±8岁,测定右房心肌和外周血淋巴细胞β受体,并作相关性分析。结果:心肌Bmax36.22±9.09fmol/mg蛋白,外周血Bmax16.52±2.44fmol/10~6 cells(X±SD),心肌与外周血淋巴细胞β-受体直线回归相关系数r=0.749,(P<0.05)。结果表明:本研究结果显示心肌与外周血淋巴细胞β受体相关性良好,与国外报告一致,可用外周血淋巴细胞β受体进行心脏疾病临床研究。
Myocardial tissue is difficult to obtain in clinical studies. In this study, 8 cases of patients with rheumatoid arthritis were treated by ~ 3H-DHA radioligand binding method and 4 cases were treated with congenital heart surgery. The age was 30 ± 8 years old. Right atrium myocardium and peripheral blood lymphocytes β receptor, and make correlation analysis. Results: Bmax36.22 ± 9.09fmol / mg protein in myocardium and Bmax in peripheral blood were16.52 ± 2.44fmol / 10 ~ 6cells (X ± SD). Correlation coefficient of β-receptor linear regression between myocardial and peripheral blood lymphocytes was0.749 (P <0.05). The results showed that: The results of this study showed that myocardial and peripheral blood lymphocyte beta receptors correlate well, consistent with foreign reports, available peripheral blood lymphocyte beta receptor for heart disease clinical research.