Atherosclerosis(AS)is the main pathological cause of coronary heart disease(CHD).Current clinical interventions including statin drugs can effectively reduce acute myocardial infarction and stroke to some extent,but residual risk remains high.The current clinical treatment regimens are relatively effective for early atherosclerotic plaques and can even reverse their progression.However,the effectiveness of these treatments for advanced AS is not ideal,and advanced atherosclerotic plaques—the pathological basis of residual risk—can still cause a recurrence of acute cardiovascular and cerebrovascular events.Recently,nanomedicine-based treatment strategies have been extensively used in antitumor therapy,and also shown great potential in anti-AS therapy.There are many microstructures in late-stage atherosclerotic plaques,such as neovascularization,micro-calcification,and cholesterol crystals,and these have become important foci for targeted nanomedicine delivery.The use of targeted nanoparticles has become an important strategy for the treatment of advanced AS to further reduce the residual risk of cardiovascular events.Furthermore,the feasibility and safety of nanotechnology in clinical treatment have been preliminarily confirmed,in this review,we summarize the application of nanomedicine delivery in the treatment of advanced AS and the clinical value of several promising nanodrugs.