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目的探讨辽宁籍白塞综合征患者的特点。方法对2002-2005年64例辽宁籍白塞综合征患者的临床资料进行回顾性分析,并与不同国家及中国不同地区的研究结果进行比较。结果64例患者中男女之比为1∶1．2,发病年龄多见20～39岁。口腔溃疡的发生率为100％,生殖器溃疡为70．3％,眼部损害为46．9％,皮肤损害为81．3％,皮肤针刺反应阳性为70．3％,关节受累为43．8％,肾受累为35．9％,神经系统受累为25．0％,胃肠道受累为18．8％,血管受累为4．7％,心脏受累为1．6％,附睾炎为1．6％,有反复口腔溃疡家族史的为12．5％。女性结节性红斑及关节受累较男性多见(分别为P＜0．05),男性胃肠道受累多于女性(P＜0．05)。实验室检查中外周血白细胞增高的占21．9％,尿蛋白增高为15．6％,尿红细胞增高为21．9％,血细胞沉降率增快为44．0％,血IgG增高为19．2％,IgA增高为19．2％,IgM增高为10．6％,C3降低为10．6％,C4降低为8．5％,抗ANA抗体阳性为7．1％,抗ds-DNA抗体阳性为14．3％,抗ENA抗体阳性为9．5％,HLA-B*51等位基因阳性为30．0％。结论白塞综合征某些临床表现的发生率可能因地域的不同存在着差异。
Objective To investigate the characteristics of patients with Behcet’s syndrome in Liaoning Province. Methods The clinical data of 64 patients with Behcet’s Syndrome in Liaoning Province from 2002 to 2005 were retrospectively analyzed and compared with the results from different countries and regions in China. Results The ratio of male to female in 64 patients was 1: 1.2, and the onset age was more common in 20-39 years. The incidence of oral ulcers was 100%, genital ulcers 70.3%, eye damage 46.9%, skin lesions 81.3%, skin acupuncture reaction was positive 70.3%, joint involvement of 43. 8%, renal involvement 35.9%, nervous system involvement 25.0%, gastrointestinal tract involvement 18.8%, vascular involvement 4.7%, cardiac involvement 1.6%, and epididymitis 1 .6%, a family history of repeated oral ulcers was 12.5%. Women with nodular erythema and joint involvement were more common in men than in men (P <0.05, respectively), while men had more gastrointestinal involvement than women (P <0.05). In laboratory tests, peripheral blood leukocytes increased by 21.9%, urinary protein increased by 15.6%, urinary erythrocytes increased by 21.9%, blood cell sedimentation rate increased by 44.0% and blood IgG increased by 19%. 2%, IgA increased 19.2%, IgM increased 10.6%, C3 decreased 10.6%, C4 decreased to 8.5%, anti-ANA antibody positive 7.1%, anti-dsDNA antibody Positive 14.3%, anti-ENA antibody positive 9.5%, HLA-B * 51 allele positive 30.0%. Conclusions The incidence of some clinical manifestations of Behcet’s syndrome may vary according to geographical area.