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目的 探讨影响Barrett′s食管 (Barrett′sesophagus,BE)粘膜中肠上皮化生 (intestinalmeta plasia ,IM)发生的因素。 方法 应用胃镜下和组织学染色方法诊断IM ,并比较 36例存在IM的BE患者与 11例不伴有IM的BE患者在年龄、胃镜下表现及食管运动功能方面的特点。结果 BE患者的年龄、胃镜下BE粘膜的长度及形态 ,均与IM的发生率有关 (P <0 .0 5 ) ;但食管炎的程度及食管运动功能与IM的发生率无关 (P >0 .0 5 )。结论 年龄在 30岁以上、胃镜下舌型BE及长度 3.5cm以上与IM的发生率增加 ,可作为判断BE预后及筛选随访的临床参考指标 ;食管运动功能障碍在BE发生肠上皮化生的过程中可能不起主要作用
Objective To investigate the factors that affect the intestinal mucosal metaplasia (IM) in Barrett’s esophagus (BE). Methods Gastroscopy and histological staining were used to diagnose IM. The age, endoscopy and esophageal motility were compared between 36 patients with BE and 11 without BE. Results The age of BE patients and the length and shape of BE mucosa under endoscopy were related to the incidence of IM (P <0.05). However, the degree of esophagitis and esophageal motility were not related to the incidence of IM (P> 0) .0 5). Conclusions The age above 30 years old, tongue type BE under gastroscope and the length of 3.5cm and IM increased incidence, can be used as a judgment of BE prognosis and screening follow-up clinical reference; esophageal dysfunction in the process of intestinal metaplasia of BE May not play a major role