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目的研究洛铂混合碘油动脉内栓塞治疗大肝癌的临床效果。方法选取邯郸市第二医院2013年9月—2014年9月收治的大肝癌患者48例,随机分为观察组和对照组,各24例。观察组患者采用洛铂混合碘油动脉内栓塞治疗,对照组患者采用化疗治疗,观察两组患者的临床效果以及毒副作用发生情况。结果观察组总有效率为79.71%,高于对照组的41.67%,差异有统计学意义(P<0.05)。治疗前两组白细胞、血小板、红细胞计数比较,差异无统计学意义(P>0.05)。治疗后2周两组白细胞、血小板计数比较,差异有统计学意义(P<0.05);两组红细胞计数比较,差异无统计学意义(P>0.05)。两组治疗前后的白细胞、血小板计数组内比较,差异有统计学意义(P<0.05)。观察组恶心、呕吐、白细胞计数降低、心肌受损、骨髓抑制发生率低于对照组,差异有统计学意义(P<0.05)。结论洛铂混合碘油动脉内栓塞治疗大肝癌的效果确切,安全性好。
Objective To study the clinical effect of intra-arterial embolization of lobaplatin mixed iodoform oil in treating large hepatocellular carcinoma. Methods Forty-eight patients with major liver cancer who were admitted to Handan Second Hospital from September 2013 to September 2014 were randomly divided into observation group and control group, with 24 cases in each group. Patients in the observation group were treated with intra-arterial embolization of lobaplatin mixed with iodized oil, and patients in the control group were treated with chemotherapy. The clinical effects and side-effects of the two groups were observed. Results The total effective rate in the observation group was 79.71%, which was higher than that in the control group (41.67%), the difference was statistically significant (P <0.05). There was no significant difference in leucocyte, platelet and erythrocyte count between the two groups before treatment (P> 0.05). There were significant differences in leucocyte and platelet counts between the two groups after 2 weeks of treatment (P <0.05). There was no significant difference in erythrocyte count between the two groups (P> 0.05). Before and after treatment of leukocytes, platelet count within the group, the difference was statistically significant (P <0.05). The observation group had nausea, vomiting, decreased white blood cell count, myocardial damage, and the incidence of bone marrow suppression was lower than that of the control group (P <0.05). Conclusions Losartan mixed iodoform oil endarterectomy for the treatment of large liver cancer is exact and safe.