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血脑屏障（ BBB）是维持中枢神经系统（ CNS）内环境稳定的结构基础，当血脑屏障受到破坏后，会导致一系列CNS相关性疾病的发生。近几年的研究发现，PKC信号通路在血脑屏障的损伤中扮演着重要角色，通过深入研究PKC信号通路在血脑屏障损伤中的作用机制，可以更好的阐明血脑屏障损伤的机制，为血脑屏障损伤相关的CNS性疾病的早期预防、诊断和预后提供新的策略。“,”Brain blood barrier ( BBB) is stable internal environment to maintain the structural basis of the central nervous system ( CNS) , when the blood-brain barrier damage, it will lead to a series of CNS-related diseases.In recent years, studies have found that PKC signaling pathway plays an important role in the brain blood barrier damage, through in-depth study of PKC signaling pathway BBB injury mechanism, it can better elucidate the mechanism of the brain blood barrier dam-age, provide new strategies for the brain blood barrier early prevention, diagnosis and prognosis damage in CNS diseases.