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目的:探讨中西药结合治疗外阴上皮内非瘤样病变的近远期疗效,评价中西药结合治疗的有效性、安全性及可行性。方法:对2006年4月～2007年4月,采用中西药结合治疗的79例外阴上皮内瘤样病变患者的临床资料进行回顾性分析,其中鳞状上皮增生型46例(占58%),硬化性苔癣型33例(占41%)。患者年龄19～80岁,平均年龄43.9岁,于治疗后6、12个月评价疗效。结果:79例患者随访资料完整,治疗6个月,临床治愈45例(占56%),有效32例(占40),无效2例(占2%),治疗6个月的有效率为97%,治疗12个月的有效率为93%。治疗12个月后有3例患者再次出现外阴瘙痒症状(占3%),经过3个月治疗,症状完全缓解。79例患者中无1例出现阴道周围组织损伤等并发症。结论:中西药结合治疗外阴上皮内瘤样病变是目前行之有效的治疗方法,治疗方法简便、安全无创、复发率低,值得在临床上推广应用。
Objective: To explore the short-term and long-term curative effect of combination of Chinese and western medicine on non-vulvar intraepithelial neoplasia and to evaluate the efficacy, safety and feasibility of the combination of Chinese and Western medicine. Methods: From April 2006 to April 2007, 79 cases of vulvar intraepithelial neoplasia with Chinese-Western medicine were retrospectively analyzed. Among them, 46 cases (58%) had squamous cell hyperplasia, 33 cases of lichen sclerosus type (41%). Patients aged 19 to 80 years, mean age 43.9 years, 6,12 months after treatment to evaluate the efficacy. Results: The data of 79 patients were followed up for 6 months, 45 cases were cured (56%), 32 cases were effective (40%), 2 cases were invalid (2%), and the effective rate was 97 %, The effective rate of 12 months of treatment was 93%. After 12 months of treatment, 3 cases of genital itching again symptoms (3%), after 3 months of treatment, symptoms completely relieved. None of the 79 patients had complications such as tissue injury around the vagina. Conclusion: The combination of Chinese and western medicine in the treatment of vulvar intraepithelial neoplasia is an effective treatment, the treatment is simple, safe and noninvasive, the recurrence rate is low, it is worth popularizing the clinical application.