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环孢素A(cyclosporin A,CsA)是一种具有划时代意义的免疫抑制剂,它在血液科的应用越来越受到广大血液科医生的关注。日前,本报记者就CsA在血液系统疾病方面的应用采访了天津中国医科院血液学研究所、血液病医院邵宗鸿教授和北京大学人民医院血液病研究所黄晓军教授。 CsA的特点 邵宗鸿:CsA有三大特点:①CsA具有特异性抑制T淋巴细胞作用,可用于治疗T细胞功能亢进性疾病。②CsA通过抑制T细胞,间接抑制B细胞,可治疗大部分自身免疫性疾病。③CsA与其他免疫抑制剂如硫唑嘌岭、硫鸟嘌呤、环磷酰胺
Cyclosporin A (CsA) is an epoch-making immunosuppressive agent. Its application in hematology is getting more and more attention from the majority of hematologists. A few days ago, our reporter interviewed Professor Shao Zonghong of Hematology Hospital and Professor Huang Xiaojun of Peking University People’s Hospital Institute of Hematology on the application of CsA in hematological diseases. Characteristics of CsA Shao Zonghong: CsA has three major characteristics: ① CsA has a specific inhibitory effect of T lymphocytes can be used to treat T cell hyperthyroidism. ②CsA can inhibit most autoimmune diseases by inhibiting T cells and indirectly inhibiting B cells. ③CsA and other immunosuppressive agents such as azathioprine, thioguanine, cyclophosphamide