近年来,ICSI对男性不育的治疗取得了极大的成功。然而,精子的遗传学异常所带来的遗传风险引起了较大的关注。在这些不育症患者中,大部分的少弱精子症患者和部分无精子症患者选择了ICSI,所以对患少弱精子症和无精子症的男性不育夫妇进行遗传学咨询与筛查,对防止这种基因缺陷的遗传具有重要意义。本综述就不育男性的遗传学缺陷发生率进行了分析。 In recent years, ICSI has achieved great success in the treatment of male infertility. However, the genetic risks associated with genetic abnormalities in sperm have drawn much attention. In these infertility patients, the majority of patients with oligoasthenospermia and some patients with azoospermia chose ICSI, so genetic counseling and screening of male infertility couples with asthenospermia and azoospermia, It is of great importance to prevent the genetic defects of this gene. This review examines the incidence of genetic defects in infertile men.