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目的比较施多宁、佳息患联合治疗与国产药物去羟肌苷散、司他夫定和奈韦拉平三药联合治疗人类免疫缺陷病毒(HIV)感染者1年时的疗效及不良反应。方法HIV感染者分为2组,一组26例,给予施多宁、佳息患联合治疗;另一组(对照组)38例,给予国产药物去羟肌苷散、司他夫定和奈韦拉平3药联合治疗,均随访1年,监测患者的血浆病毒载量及CD4+T淋巴细胞计数,并评价药物不良反应。结果经过1年治疗两组患者血浆中HIV RNA含量均明显降低,CD4+T淋巴细胞数量增加,药物不良反应轻微。结论施多宁、佳息患联合治疗组和国产药物三联治疗组在一年的观察中均能有效抑制HIV病毒的复制,机体免疫功能也有所改善。两组疗效和不良反应的差别无显著性意义。
Objective To compare the efficacy and side effects of combination therapy of STD and STD with domestic three-drug combination of didanosine, stavudine and nevirapine for 1 year in patients with HIV infection. Methods HIV-infected patients were divided into two groups, one group of 26 patients, given combination of dodonin, good interest treatment; the other group (control group) 38 patients were given domestic drug didanosine powder, stavudine and nevirapine 3 drug combination therapy, were followed up for 1 year to monitor the patient’s plasma viral load and CD4 T lymphocyte count, and evaluation of adverse drug reactions. Results After 1 year of treatment, the plasma HIV RNA levels in both groups were significantly decreased, the number of CD4 + T lymphocytes increased, and adverse drug reactions were slight. Conclusion Sfogonin, the combination therapy of good interest and the triple therapy of domestic drug can effectively inhibit the replication of HIV virus in one year of observation, and the immune function of the body is also improved. There was no significant difference between the two groups in efficacy and adverse reactions.