LIRs是新近发现的另一类MHCI类分子受体 ,它不仅存在于NK细胞和T细胞表面 ,还在单核细胞、树突状细胞、B细胞等细胞表面表达。不同种类的LIRs通过传导抑制性或刺激性信号发挥广泛的免疫调节作用 ,在抑制杀伤性免疫细胞的杀伤活性 ,调节树突状细胞与T细胞之间的信号交流 ,调节B细胞的激活阈 ,参与树突状细胞的抗原俘获以及防止母亲NK细胞对胎儿组织的攻击等方面均具有重要的生物学意义 LIRs is another recently discovered MHC class I molecule receptor that not only exists on the surface of NK cells and T cells but also on the surface of monocytes, dendritic cells and B cells. Different types of LIRs exert extensive immunomodulatory effects by inhibiting inhibitory or stimulatory signals, inhibit the cytotoxic activity of killer immune cells, modulate the signal exchange between dendritic cells and T cells, regulate the activation threshold of B cells, It has important biological significance to participate in the antigen capture of dendritic cells and prevent the mother’s NK cells from attacking fetal tissues