雌激素作为一种内分泌激素 ,在神经系统中发挥着重要的作用 ,除了对性别分化和神经内分泌的调节外 ,还表现出对神经毒性的防护作用。其神经保护作用与雌激素受体途径、调节兴奋性氨基酸受体功能、维持胞内钙稳态、与神经生长因子相互作用、抑制细胞凋亡、调节质膜功能和免疫炎症反应等有关。本文拟就雌激素对神经毒性的作用及途径进行综述 Estrogen, as an endocrine hormone, plays an important role in the nervous system. In addition to the regulation of gender differentiation and neuroendocrine, estrogen also shows neuroprotective protective effect. Its neuroprotection and estrogen receptor pathway, regulating excitatory amino acid receptor function, maintaining intracellular calcium homeostasis, interaction with nerve growth factor, inhibiting apoptosis, regulating plasma membrane function and immune inflammation. This article intends to estrogen on the neurotoxic effects and pathways are reviewed