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DNA甲基化是很多恶性肿瘤的发病机制。甲基化能够导致抑癌基因的表达沉默,使正常细胞的生长分化调控失常以及DNA损伤不能及时修复,导致肿瘤形成。近年研究表明,Kaposi肉瘤(KS)的形成与TβRⅡ基因(转化生长因子Ⅱ型受体基因)、p16IN K4A基因、Axl基因(受体酪氨酸激酶基因)发生甲基化有关。另外,甲基化是个可逆过程,5-氮-2’-脱氧胞苷(5-aza-CdR)能够使表达沉默的抑癌基因重新激活,有可能成为KS治疗的一个新途径。
DNA methylation is the pathogenesis of many malignancies. Methylation can cause the expression of tumor suppressor gene silencing, abnormal growth and differentiation of normal cells and DNA damage can not be repaired in time, leading to tumor formation. Recent studies have shown that the formation of Kaposi’s sarcoma (KS) is related to the methylation of TβRⅡ gene (transforming growth factor Ⅱ receptor gene), p16IN K4A gene and Axl gene (receptor tyrosine kinase gene). In addition, methylation is a reversible process. 5-aza-CdR can reactivate the tumor suppressor gene silenced and may be a new way of KS therapy.