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目的观察羟苯磺酸钙胶囊联合丹参注射液治疗老年2型糖尿病早期视网膜病变的临床疗效及安全性。方法将58例老年2型糖尿病早期视网膜病变患者随机分为对照组29例和试验组29例。对照组予以羟苯磺酸钙每次0.5g,tid,口服;试验组在对照组治疗的基础上,予以丹参注射液20 mL,qd,静脉滴注,治疗2周停药1周。2组患者均治疗3个月。比较2组患者的临床疗效、血管内皮细胞生长因子(VEGF)、胰岛素样生长因子1(IGF-1)、超敏C-反应蛋白(hs-CRP)水平,以及药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为93.10%(27/29例)和72.41%(21/29例),差异有统计学意义(P<0.05)。治疗后,试验组和对照组的血清VEGF分别为(82.32±9.73)和(105.24±10.05)pg·mL~(-1),IGF-1分别为(89.66±8.79)和(124.24±9.86)ng·mL~(-1),hs-CRP分别为(3.98±0.52)和(6.76±0.83)mg·L~(-1),差异均有统计学意义(均P<0.05)。试验组的药物不良反应主要有面部潮红和恶心呕吐,对照组的药物不良反应主要有恶心呕吐和食欲缺乏。试验组和对照组的药物不良反应发生率分别为10.34%和6.90%,差异无统计学意义(P>0.05)。结论羟苯磺酸钙胶囊联合丹参注射液治疗老年2型糖尿病早期视网膜病变的临床疗效显著,其能够明显降低患者的血清VEGF、IGF-1及hs-CRP水平,且不增加药物不良反应的发生率。
Objective To observe the clinical efficacy and safety of calcium dobesilate combined with Salvia miltiorrhiza in the treatment of early diabetic retinopathy in elderly patients. Methods Fifty-eight elderly patients with type 2 diabetic retinopathy were randomly divided into control group (29 cases) and experimental group (29 cases). The control group was given calcium dobesilate 0.5g, tid, oral; experimental group in the control group based on the treatment, to be Danshen injection 20 mL, qd, intravenous infusion, treatment for 2 weeks for 1 week. Two groups of patients were treated for 3 months. The clinical efficacy, the levels of vascular endothelial growth factor (VEGF), insulin-like growth factor 1 (IGF-1), and hs-CRP in the two groups were compared. The incidence of adverse drug reactions was also compared. Results After treatment, the total effective rates of the experimental group and the control group were 93.10% (27/29 cases) and 72.41% (21/29 cases) respectively, the difference was statistically significant (P <0.05). After treatment, the serum VEGF of the experimental group and the control group were (82.32 ± 9.73) and (105.24 ± 10.05) pg · mL -1, respectively, and the IGF-1 levels were 89.66 ± 8.79 and 124.24 ± 9.86 ng · ML -1 and hs-CRP were (3.98 ± 0.52) and (6.76 ± 0.83) mg · L -1, respectively (all P <0.05). Adverse drug reactions in the experimental group were mainly facial flushing and nausea and vomiting. The adverse drug reactions in the control group were mainly nausea and vomiting and lack of appetite. The incidence of adverse drug reactions in the experimental group and the control group were 10.34% and 6.90%, respectively, with no significant difference (P> 0.05). Conclusion Calcium dobesilate combined with Salvia miltiorrhiza injection in the treatment of early type 2 diabetic patients with early diabetic retinopathy has a significant clinical effect, which can significantly reduce the serum levels of VEGF, IGF-1 and hs-CRP, and does not increase the incidence of adverse drug reactions rate.