单独使用IL-2治疗实体瘤引起的主要副作用是血管渗漏综合症(VLS),是由血管通透性的增加所引起。体外实验证明,IL-2能够促进淋巴细胞与培养的内皮细胞粘附,而粘附的淋巴细胞则直接或通过产生IFN,TNF,CSF 或其他细胞因子而间接地增加血管的通透性。通过以下体内实验可证明上述结论:①运用活体显微术检测白 The main side effect caused by the treatment of solid tumors with IL-2 alone is vascular leak syndrome (VLS), which is caused by an increase in vascular permeability. In vitro experiments demonstrated that IL-2 promotes adhesion of lymphocytes to cultured endothelial cells, whereas adherent lymphocytes indirectly increase vascular permeability, either directly or through the production of IFN, TNF, CSF or other cytokines. The above conclusions can be proved by the following in vivo experiments: ① using live microscopy to detect white