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以除草剂丁草胺溶液为染毒药物,以小鼠为实验对象,利用Morris水迷宫系统研究了丁草胺对小鼠的急性致死效应和空间记忆能力的影响.实验结果表明:丁草胺对小鼠的LD50为22.74 mg/kg(95%的置信区间为15.17~34.52 mg/kg).除个别低剂量处理组外,大部分的丁草胺处理组的平均潜伏逃避时间、平均游泳距离都明显长于空白对照组,而且均达到了差异显著水平(P<0.05)或差异极显著水平(P<0.01或P<0.001).实验还发现不同的入水次序和入水象限对小鼠的空间记忆能力有较大的影响.在第1象限(目标象限)入水和第4入水次序时,小鼠的平均逃避潜伏时间和平均游泳距离均较短.
The herbicide butachlor solution was used as the drug and the mice were used as experimental objects to study the effect of butachlor on acute lethal effect and spatial memory in mice by Morris water maze system.The experimental results showed that butachlor The LD50 for mice was 22.74 mg / kg (95% CI: 15.17-34.52 mg / kg). Most of the butachlor treated groups, except for the individual low-dose treatment groups, had mean latency to escape, average swimming distance Were significantly longer than the blank control group, and reached a significant difference (P <0.05) or significant difference (P <0.01 or P <0.001) .The experiment also found that different inflow sequence and water quadrant on mice spatial memory Ability to have a greater impact in the first quadrant (target quadrant) into the water and the fourth into the water sequence, the average mouse escape latency and average swimming distance are shorter.