1982年9月28日,一名健康的19岁青年突然体温升高至40℃,伴有头痛、肌痛,但无寒战、颈项强直及咽炎,脉搏高达120次/分。36小时后,症状持续存在,并查及脾肿大但未触及浅表淋巴结,其余临床检查均正常。9月30日血常规为:红细胞531万,白细胞8100,其中中性粒细胞为57%、嗜碱性粒细胞为1%、淋巴细胞为8%、单核细胞为3%、超嗜硷性大单核细胞(mononucléaire On September 28, 1982, a healthy 19-year-old man suddenly had an elevated body temperature of 40 ° C with headache and myalgia but without chills, neck stiffness and pharyngitis, with a pulse of 120 beats / min. After 36 hours, the symptoms persisted, and splenomegaly was detected but no superficial lymph nodes were touched, and the remaining clinical tests were normal. September 30 routine blood: 5310000 red blood cells, 8100 white blood cells, of which 57% of neutrophils, basophils 1%, 8% of lymphocytes, monocytes 3%, hyper-basophilic Large mononuclear cells (mononucléaire