论文部分内容阅读
本工作应用大鼠离体心脏和培养的心肌细胞结合心钠素的放射免疫测定,研究了降钙素基因相关肽对心钠素释放的影响。结果发现,无论在离体心脏或培养的心肌细胞,降钙素基因相关肽均可引起心钠素的释放,并具有剂量效应关系;降钙素基因相关肽对心钠素的释放作用可能不完全依赖于Ca~(2+)的存在。提示心钠素的释放受降钙素基因相关肽的调节。
In this study, the effects of calcitonin gene-related peptide on the release of atrial natriuretic peptide were studied by radioimmunoassay using isolated rat heart and cultured cardiomyocytes combined with atrial natriuretic peptide. The results showed that calcitonin gene-related peptide can cause the release of atrial natriuretic peptide and have a dose-response relationship in isolated heart or cultured cardiomyocytes. The release of calcitonin gene-related peptide may not be related to the release of atrial natriuretic peptide Completely dependent on the existence of Ca ~ (2+). Suggesting that the release of atrial natriuretic peptide is regulated by calcitonin gene-related peptide.