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The chemical reaction of progesterone with su-peroxide anion O2- in 0.1 mol/L NaHCO3 medium is studied by polarography. Differing from the indirect inhibition of O2- generation by synthesized glucocorticoids in mecha-nism, the function that progesterone scavenges O2- is as-cribed to that O2- directly oxidizes the C =C double bond conjugated with the carbonyl moiety of progesterone mole-cule to a free radical, and then is reduced to H2O2. The result obtained in this work gives new evidence for biomedical research. The equation of rate constant of the oxidization reaction is deduced, and the apparent rate constant obtained is308 L·mol-1·s-1.
The chemical reaction of progesterone with su-peroxide anion 02- in 0.1 mol / L NaHCO3 medium is studied by polarography. Differing from the indirect inhibition of O2- generation by finished glucocorticoids in mecha-nism, the function that progesterone scavenges O2- is as -cribed to that O2- directly oxidizes the C = C double bond conjugated with the carbonyl moiety of progesterone mole-cule to a free radical, and then is reduced to H2O2. The result obtained in this work gives new evidence for biomedical research. The equation of rate constant of the oxidization reaction is deduced, and the apparent rate constant is obtained as 308 L · mol-1 · s-1.