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目的探讨D2-40在胸腺上皮肿瘤(TET)中的表达,分析D2-40表达与肿瘤侵袭和预后的关系。方法采用免疫组织化学染色法观察D2-40在160例胸腺上皮肿瘤和40例正常胸腺标本中的表达情况,术后连续随访5年以上。应用统计学软件分析D2-40表达与肿瘤侵袭和预后的关系。结果 D2-40在TET及正常胸腺中的阳性表达率分别为58.8%(94/160)和20%(8/40),差异有统计学意义(P=0.013)。D2-40在TET中的表达与TET侵袭性有关(P<0.01)。D2-40阳性表达组和阴性表达组患者5年生存率分别为32%、90%(P<0.01)。结论D2-40在TET中的表达高于正常胸腺组织,且随着侵袭性的增强,表达也增强。D2-40表达阳性的患者预后较差。
Objective To investigate the expression of D2-40 in thymus epithelial tumor (TET) and analyze the relationship between D2-40 expression and tumor invasion and prognosis. Methods Immunohistochemical staining was used to observe the expression of D2-40 in 160 cases of thymic epithelial tumor and 40 cases of normal thymus. The patients were followed up for more than 5 years. The relationship between D2-40 expression and tumor invasion and prognosis was analyzed by statistical software. Results The positive rates of D2-40 in TET and normal thymus were 58.8% (94/160) and 20% (8/40), respectively, with significant difference (P = 0.013). The expression of D2-40 in TET was associated with TET invasiveness (P <0.01). The 5-year survival rates of patients with D2-40 positive expression group and negative expression group were 32% and 90%, respectively (P <0.01). Conclusion The expression of D2-40 in TET is higher than that in normal thymus tissue, and the expression of D2-40 is also enhanced with the increase of invasiveness. Patients with a positive expression of D2-40 have a poor prognosis.