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以泊洛沙姆407和泊洛沙姆188为温度敏感基质材料,海藻酸钠和羟丙甲纤维素E50LV为离子敏感基质材料,制备盐酸莫西沙星离子-温度双敏感眼用原位凝胶。通过考察不同基质对成胶温度、成胶时间、黏度和体外释放行为的影响,得到优化处方组成为:海藻酸钠0.5%,羟丙甲纤维素0.3%,泊洛沙姆188 5.9%和泊洛沙姆407 17.7%。该制品在室温下为自由流动的液体,经人工泪液稀释后在33℃时能发生相变形成凝胶,在体外4 h时基本释放完全。
To poloxamer 407 and poloxamer 188 as temperature-sensitive matrix material, sodium alginate and hypromellose E50LV as ion-sensitive matrix material, the preparation of moxifloxacin hydrochloride ion temperature dual-sensitive in situ gels. By investigating the effects of different matrices on the gelation temperature, the gelation time, the viscosity and the in vitro release behavior, the optimized formulation consisted of sodium alginate 0.5%, hypromellose 0.3%, poloxamer 188 5.9% and poloxamer Sharm 407 17.7%. The product at room temperature as a free-flowing liquid, diluted by artificial tears at 33 ° C when the phase change can form a gel, 4 h in vitro, the basic release completely.