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目的探讨慢性阻塞性肺疾病(COPD)急性加重期和稳定期患者血清C反应蛋白(CRP)水平、肺功能、血气分析指标的变化。方法选取2013年8月—2014年10月在高安市人民医院住院治疗的COPD急性加重期患者和稳定期患者各50例,分别作为急性期组和稳定期组,选取同期体检健康者30例作为对照组,检测3组的血清CRP水平、第1秒用力呼气容积(FEV1)、第1秒用力呼气容积与用力肺活量比值(FEV1/FVC)、动脉血氧分压(Pa O2)、二氧化碳分压(Pa CO2)。结果 3组CRP、FEV1、FEV1/FVC、Pa O2、Pa CO2水平比较,差异有统计学意义(P<0.05)。急性期组CRP、Pa CO2水平高于稳定期组和对照组,FEV1、FEV1/FVC、Pa O2低于稳定期组和对照组,差异有统计学意义(P<0.05);稳定期组CRP、Pa CO2水平高于对照组,FEV1、FEV1/FVC、Pa O2低于对照组,差异有统计学意义(P<0.05)。血清CRP水平与FEV1、FEV1/FVC、Pa O2呈负相关(r=-0.483、-0.422、-0.406,P<0.05),与Pa CO2呈正相关(r=0.514,P<0.05)。结论 CRP可作为判断COPD急性加重的炎性标志物,与患者肺功能及血气分析指标密切相关。
Objective To investigate the changes of serum C-reactive protein (CRP), pulmonary function and blood gas analysis in patients with chronic obstructive pulmonary disease (COPD) in acute exacerbation and stable phases. Methods A total of 50 acute COPD exacerbation patients and 50 stable COPD patients were enrolled in the Gaoan Municipal People’s Hospital from August 2013 to October 2014. The patients were selected as the acute group and the stable group respectively. In the control group, serum CRP level, FEV1, FEV1 / FVC, Pa O2, carbon dioxide Partial pressure (Pa CO2). Results The CRP, FEV1, FEV1 / FVC, Pa O2 and Pa CO2 levels in the three groups were significantly different (P <0.05). The levels of CRP and PaCO 2 in acute phase group were significantly higher than those in stable phase group and control group, while FEV 1, FEV 1 / FVC and Pa O 2 were lower than those in stable group and control group (P <0.05) Pa CO2 level was higher than the control group, FEV1, FEV1 / FVC, Pa O2 lower than the control group, the difference was statistically significant (P <0.05). Serum CRP level was negatively correlated with FEV1, FEV1 / FVC and Pa O2 (r = -0.483, -0.422, -0.406, P <0.05), and positively correlated with PaCO2 (r = 0.514, P <0.05). Conclusion CRP can be used as an inflammatory marker to judge acute exacerbation of COPD, which is closely related to pulmonary function and blood gas analysis index.