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用免疫组化方法探讨庆大霉素耳中毒时蜗核ＳＰ免疫反应神经元的胞体截面积及细胞数的变化。结果发现庆大霉素１００ｍ ｇ·ｋｇ－ １·ｄ－ １腹腔注射后１ｄ，豚鼠蜗核ＳＰ样神经元胞体截面积立即发生了变化，并持续到连续注药第２１ 天；ＳＰ样神经元细胞数量的相对变化发生在注药３ｄ 以后。结果提示：①庆大霉素中毒豚鼠蜗核神经元的变化和耳蜗的病变可能同时发生或蜗核早于耳蜗病变。②临床上治疗氨基甙类抗生素所致耳聋应兼治中枢病变并尽早实施
Immunohistochemistry was used to investigate the change of cell body area and cell number of SP immunoreactive neurons in cochlear nucleus during gentamicin ototoxicity. The results showed that the cross-sectional area of cytoplasm of SP-like neurons in cochlear nuclei of guinea-pigs immediately changed 1 day after gentamicin 100m g · kg-1 · d-1 intraperitoneal injection and lasted for 21 days. SP-like neurons The relative changes in the number of cells occurred after 3d injection. The results suggest: ① gentamicin poisoning guinea pig cochlear neurons changes and cochlear lesions may occur at the same time or the cochlear nucleus earlier than the cochlear lesions. ② clinical treatment of aminoglycoside antibiotic-induced central degeneration and should be implemented as soon as possible