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目的探讨乳腺导管原位癌超声征象与免疫组化指标雌激素受体(ER)、孕激素受体(PR)和人表皮生长因子受体2(HER-2)表达的相关性。方法选择2010年5月至2013年10月收治的60例乳腺导管原位癌患者,均给予彩色多普勒超声及ER、PR和HER-2表达的免疫组化分析。结果超声表现:36例表现为肿块有边缘毛刺,34例表现肿块后方回声衰减,30例表现为肿块伴微钙化,血流丰富者31例。免疫分析:ER阳性率为56.7%,PR阳性率为75.0%,HER-2过表达率为30.0%。边缘毛刺征组和后方声衰减组的ER阳性率表达都明显增加(P<0.05),微钙化组的HER-2过表达率明显增加(P<0.05)。结论在乳腺癌中,毛刺征、后方声衰减征象可在一定程度上反映ER的表达情况,钙化征象可反映HER-2的表达情况。
Objective To investigate the correlation between the echocardiographic features of breast duct carcinoma in situ and the immunohistochemical expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER-2). Methods Sixty patients with ductal carcinoma in situ from May 2010 to October 2013 were selected and analyzed by color Doppler sonography and immunohistochemical analysis of ER, PR and HER-2 expression. Results Ultrasound: 36 cases showed edge burr, 34 cases showed echogenic attenuation, 30 cases showed mass with microcalcification, 31 cases of rich blood flow. Immunoassay: ER positive rate was 56.7%, PR positive rate was 75.0%, HER-2 overexpression rate was 30.0%. The expression of ER positive rate in marginal spiculation group and posterior acoustic decay group were significantly increased (P <0.05), while the overexpression of HER-2 in microcalcification group was significantly increased (P <0.05). Conclusion In breast cancer, the signs of glitch and posterior acoustic decay may reflect the expression of ER to a certain extent, and the signs of calcification may reflect the expression of HER-2.