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基质金属蛋白酶抑制剂(TIMPs)是基质金属蛋白酶(MMPs)的特异性抑制剂,两者比例失常将导致细胞外基质合成和降解失去平衡,促进肝纤维化的形成。TIMPs表达的异常在肝纤维化形成过程中具有非常重要的作用,本文对TIMPs在肝纤维化形成中的变化及其对肝纤维化诊断、治疗等方面的作用作一综述。
Matrix metalloproteinases inhibitors (TIMPs) are specific inhibitors of matrix metalloproteinases (MMPs). The imbalance between the two leads to a loss of balance in the synthesis and degradation of extracellular matrix and the promotion of hepatic fibrosis. The abnormal expression of TIMPs plays a very important role in the formation of hepatic fibrosis. This review summarizes the changes of TIMPs in the formation of hepatic fibrosis and its role in the diagnosis and treatment of hepatic fibrosis.