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目的探讨E-钙黏蛋白(E-Cadherin,E-Cad)在喉鳞状细胞癌侵袭转移中的作用,旨在初步明确其在喉鳞状细胞癌淋巴结转移判断中的作用。方法应用免疫组化S-P法检测66例喉鳞状细胞癌标本中E-Cad的表达情况,以其癌旁正常黏膜作为对照,并分析比较E-Cad表达与喉鳞状细胞癌患者年龄、病理分级、临床分期、临床分型、淋巴结转移等方面的关系,探讨其临床意义。结果E-Cad在喉鳞状细胞癌组织中阳性表达率为3.0%,在癌旁正常黏膜中75.8%,两者比较差异有显著性(P<0.05)。E-Cad阴性表达率与喉鳞状细胞癌患者的年龄、临床分期、临床分型以及淋巴结转移有显著性相关(P<0.05);而与病理分级方面无显著性相关(P>0.05)。结论E-Cad可能是喉鳞状细胞癌侵袭转移机制中的重要肿瘤标志物,它对于喉鳞状细胞癌淋巴结转移的判断具有重要意义。
Objective To investigate the role of E-cadherin (E-Cadherin) in the invasion and metastasis of laryngeal squamous cell carcinoma (LSCC), and to clarify the role of E-Cadherin in the detection of lymph node metastasis in laryngeal squamous cell carcinoma. Methods Immunohistochemical SP method was used to detect the expression of E-Cad in 66 specimens of laryngeal squamous cell carcinoma. The normal mucosa of paracancer was used as a control. The expression of E-cad was compared with the age and pathology of laryngeal squamous cell carcinoma Grade, clinical stage, clinical classification, lymph node metastasis and other aspects of the relationship between the clinical significance. Results The positive rate of E-cadherin in laryngeal squamous cell carcinoma was 3.0% and that in normal mucosa was 75.8%, which was significantly different between the two groups (P <0.05). The negative rate of E-Cad expression was significantly correlated with the age, clinical stage, clinical classification and lymph node metastasis of laryngeal squamous cell carcinoma (P <0.05), but not with the pathological grade (P> 0.05). Conclusion E-Cad may be an important tumor marker in the invasion and metastasis of laryngeal squamous cell carcinoma, which is of great significance for the judgment of lymph node metastasis of laryngeal squamous cell carcinoma.