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目的研究探讨奥美拉唑四联疗法治疗小儿消化性溃疡合并幽门螺杆菌感染的疗效。方法选取我院于2015年1月至2016年3月期间收治的60例小儿消化性溃疡合并幽门螺杆菌感染患儿为研究对象,将其随机分为观察组(30例)与对照组(30例),对照组给予奥美拉唑三联疗法进行治疗,观察组给予奥美拉唑四联疗法进行治疗。比较两组患儿治疗疗效及幽门螺杆菌检测的阳性率。结果治疗后,观察组患儿治疗总有效率明显高于对照组,差异显著(P<0.05);观察组患儿检测幽门螺杆菌阳性率明显低于对照组,差异显著(P<0.05)。结论小儿消化性溃疡合并幽门螺杆菌感染采用奥美拉唑四联疗法治疗临床疗效确切,可抑制病菌的感染,促使溃疡面快速愈合,减少其不良症状的发生,提高临床治愈率,具有较高的临床应用价值。
Objective To study the effect of omeprazole quadruple therapy on children with peptic ulcer complicated with Helicobacter pylori infection. Methods Sixty children with peptic ulcer and Helicobacter pylori infection in our hospital from January 2015 to March 2016 were selected and randomly divided into observation group (30 cases) and control group (30 cases) Cases), the control group was given omeprazole triple therapy, the observation group was given omeprazole quadruple therapy for treatment. The curative effect of Helicobacter pylori and the positive rate of Helicobacter pylori were compared between the two groups. Results After treatment, the total effective rate in observation group was significantly higher than that in control group (P <0.05). The positive rate of Helicobacter pylori in observation group was significantly lower than that in control group (P <0.05). Conclusions Pediatric peptic ulcer with Helicobacter pylori infection with omeprazole quadruple therapy has the definite clinical curative effect, which can restrain the infection of bacteria, promote the healing of ulcer surface, reduce the occurrence of adverse symptoms and improve the clinical cure rate, with higher The clinical value.