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研究了ｒｈ Ｇ Ｍ Ｃ Ｓ Ｆ 对受６０ Ｇｙ γ射线 照射复合 １５ ％ Ⅲ度 体表 烧伤 小鼠 的造 血剌 激作用。结果 表明：放 烧复合 伤后，造血 功能严 重受损，外 周血 白细胞 数明 显减 少， 以伤 后３ ～５ ｄ 最低 。骨髓有 核细胞计 数在伤 后２ｄ 内降 至最低点 。 Ｃ Ｆ Ｕ Ｇ Ｍ 也明 显低于 伤前 水平。 伤后 立即 腹腔 注射ｒｈ Ｇ Ｍ Ｃ Ｓ Ｆ（１０μｇ／ｋ ｇ·ｄ － １ ，每日一次 ，连续１０ ｄ） 后，能 明显提 高放烧复 合伤小 鼠白细 胞，骨 髓有 核细胞和粒 系祖细 胞数。提 示ｒｈ Ｇ Ｍ Ｃ Ｓ Ｆ 能从 多层次促 进放烧 复合伤造 血功能 的恢复。
The hematopoietic stimulating effect of rhG M-CS on F60 irradiated with 60 Gy γ-rays was studied. The results showed that the hematopoietic function was severely impaired and the number of leukocytes in peripheral blood decreased significantly after burn combined with burn injury, with the lowest in 3 ~ 5 d after injury. Bone marrow nucleated cell count within 2d after injury to a minimum. C F U G G also significantly lower than the pre-injury level. After intraperitoneal injection of rhG MCSF (10 μg / k g · d -1, once a day for 10 days) immediately after injury, the white blood cells, bone marrow nucleated cells and granulocytes Progenitor cells. Prompt rh G M C S F can promote the recovery of hematopoietic function of burn-burn combined injury from multiple levels.