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作者在细胞形态学、细胞化学诊断的基础上,采用一组单克隆抗体检测了8例CML-BC白血病性原始细胞分化抗原的表达特征。结果显示:3/8例POX反应阳性、形态学诊断CML-急粒变病例、免疫学检测呈现粒、单系抗体(HIM5HI98)的阳性反应,两者之间具有较好的一致性。而5/8例POX反应阴性,PAS呈阳性的病例,形态学与免疫学诊断两者之间存在较大的差异,8例均无T细胞和巨核系抗原的表达。
On the basis of cell morphology and cytochemical diagnosis, the authors used a panel of monoclonal antibodies to detect the expression characteristics of 8 CML-BC leukemia blasts. The results showed that 3/8 cases of POX positive and morphologically diagnosed CML-acute myelo-granulomatosis cases were immunologically detected with positive reaction of granule and single-line antibody (HIM5HI98) with good agreement between the two. However, 5/8 POX-negative and PAS-positive cases showed significant differences between morphologic and immunological diagnosis, and none of the 8 cases had T cell and megakaryocyte antigen expression.