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目的评估汉防己甲素治疗矽肺效果。方法矽肺46例,随机分治疗组与对照组(常规对症治疗),治疗1年,观察临床症状、肺通气功能、X线胸片影像的变化以及药物毒副作用。结果治疗组患者咳嗽、咳痰、胸闷、胸痛、气急等呼吸道症状有改善;肺通气功能(FVC、MEF50、FEV1.0%)差异性不够显著;X线胸片矽肺影像有改变,对照组变化不明显。结论汉防己甲素对早中期矽肺有一定改善作用,值得临床进一步研究和推广。
Objective To evaluate the efficacy of tetrandrine in the treatment of silicosis. Methods Forty - six patients with silicosis were randomly divided into treatment group and control group (conventional symptomatic treatment) for 1 year. The clinical symptoms, pulmonary ventilation, radiographic changes of chest X - ray and the side effects of drugs were observed. Results In the treatment group, the symptoms of respiratory tract such as cough, expectoration, chest tightness, chest pain, shortness of breath and so on were improved; the difference of pulmonary ventilation function (FVC, MEF50, FEV1.0%) was not significant; Not obvious. Conclusions Tetrandrine can improve the early and middle stage of silicosis, which deserves clinical further study and promotion.