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本研究目的是评价放－热－化（ＲＴＣＨ）三联治疗鼻咽癌颈部巨大转移灶的疗效。１３例有颈部巨大转移灶中，１０例有双侧颈部淋巴结转移。作为自身对照观察，在一侧最大径７ｃｍ以上的１０个病灶接受ＲＴＣＨ治疗，而对侧较小的１０个病灶接受ＲＴＨ治疗。另３例单侧颈部淋巴结转移且直径７ｃｍ以上的患者也接受ＲＴＨ治疗。结果显示接受ＲＴＣＨ的１３个病灶的ＣＲ率为７７％（１０／１３），较报道的ＲＴＨ的ＣＲ率５３％高。而自身对照的病灶，ＲＴＣＨ和ＲＴＨ的ＣＲ率分别为７０％（７／１０）和５０％（５／１０）。治疗过程中除化疗药物引起的一般毒副反应外，无严重毒副反应。初步研究结果提示，ＲＴＣＨ能提高鼻咽癌颈部巨大转移灶的局部控制率，方法安全
The purpose of this study was to evaluate the efficacy of radiotherapy-heating (RTCH) triple therapy in the treatment of large metastatic cervical lesions of nasopharyngeal carcinoma. Thirteen patients had metastases in the neck and 10 cases had bilateral cervical lymph node metastases. As a self-control observation, 10 lesions with a maximum diameter of 7 cm or more on one side received RTCH treatment, while 10 lesions on the opposite side received RTH treatment. The other 3 patients with unilateral cervical lymph node metastases and diameters above 7 cm were also treated with RTH. The results showed that the CR rate of 13 lesions receiving RTCH was 77% (10/13), which was 53% higher than the reported CR rate of RTH. For self-controlled lesions, CR rates for RTCH and RTH were 70% (7/10) and 50% (5/10), respectively. In addition to the general toxicities and side effects caused by chemotherapeutic drugs during the treatment, there were no serious side effects. Preliminary results suggest that RTCH can improve the local control rate of large metastatic cervical lesions in nasopharyngeal carcinoma.