论文部分内容阅读
目的：探讨肺表面活性物质（PS）对实验性急性呼吸窘迫综合征（ARDS）的治疗作用。方法：油酸诱发新西兰兔ARDS模型后分组（n＝9）治疗4h：1）对照组；2）气管内滴入PS100mg／kg（PS组）。测定动态肺顺应性（Cdyn）、动脉血气和灌洗液的总磷脂（TPL）、总蛋白（TP）、饱和卵磷脂（DSPC）、最小表面张力（STmin）、肺湿干重比（W／D）。结果：治疗后PS组各时点Cdyn和PaO2／FiO2较治疗前和同时点的对照组显著升高，TPL、DSPC／TPL和DSPC／TP较对照组显著增加，STmin和肺W／D明显降低。结论：PS对油酸型ARDS有效，可作为ARDS综合治疗的重要措施之一。
Objective: To investigate the therapeutic effect of pulmonary surfactant (PS) on experimental acute respiratory distress syndrome (ARDS). Methods: New Zealand rabbits were induced by oleic acid ARDS model group (n = 9) for 4h: 1) control group; 2) PS100mg / kg (PS group). The levels of total lipids (TPL), total protein (TP), saturated lecithin (DSPC), minimum surface tension (STmin) and W / D). Results: After treatment, the levels of Cdyn and PaO2 / FiO2 in PS group were significantly higher than those in the control group before treatment and at the same time points. The levels of TPL, DSPC / TPL and DSPC / TP were significantly increased, while the levels of STmin and lung W / D were significantly decreased . Conclusion: PS is effective for oleic ARDS and can be used as one of the important measures for ARDS.