论文部分内容阅读
目的 探讨阻塞性睡眠呼吸暂停 /低通气综合征 (OSAHS)合并红细胞增多症的临床特点及危险因素。方法 收集 1 995年 1月至 2 0 0 2年 1 2月门诊及住院的OSAHS患者的资料 ,红细胞增多症病例组与无红细胞增多症对照组按年龄、性别、体质指数及就诊时间行 1∶3匹配。分析其临床特点 ,用Logistic回归法评估发生红细胞增多的危险因素。结果 OSAHS并红细胞增多症 4 2例 ,呼吸暂停低通气指数 (AHI) >4 0 /h。红细胞容量测定符合绝对性红细胞增多症 4例、相对性红细胞增多症 38例。经鼻持续正压治疗 (nCPAP)后 ,红细胞增多症恢复的中位时间为 6d。多因素分析 ,高血压、男性、冠心病及脑卒中时发生红细胞增多症的比数比 (OR值 )分别为 1 0 .7、1 .7、1 .3及 9.1。结论 OSAHS患者引起继发性红细胞增多症仅见于少数病例 ,大多为相对性红细胞增多症 ,推测与睡眠中窒息、应激及体液减少有关。治疗OSAHS后常很快缓解。高血压、AHI >4 0、男性是发生红细胞增多症的主要因素。冠心病、脑卒中OR值增加可能为红细胞增多症的后果
Objective To investigate the clinical features and risk factors of obstructive sleep apnea / hypopnea syndrome (OSAHS) complicated with polycythemia. METHODS: The data of patients with OSAHS from January 1995 to January 2012 were collected. The patients with polycythemia and non-polycythemia patients were divided into two groups according to age, gender, body mass index and time of visit: 3 matches. The clinical features were analyzed and Logistic regression was used to assess the risk factors for erythrocyte increase. Results OSAHS and polycythemia in 42 cases, apnea hypopnea index (AHI)> 40 / h. Erythrocyte volume measured in line with 4 cases of absolute polycythemia, 38 cases of relative polycythemia. After nasal continuous positive pressure treatment (nCPAP), the median time to recovery of polycythemia was 6 days. The odds ratios (OR) for multivariate analysis, hypertension, males, coronary heart disease and stroke were 1.07, 1.7, 1.3 and 9.1, respectively. Conclusions OSAHS patients with secondary polycythemia only found in a few cases, mostly relative polycythemia, presumably with sleep apnea, stress and body fluid reduction related. After treatment of OSAHS often quickly remission. Hypertension, AHI> 40, men are the main factors in the occurrence of polycythemia. Coronary heart disease, stroke OR value may be the consequences of polycythemia