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目的 探讨头颈部恶性肿瘤患者手术前后血清一氧化氮水平变化的意义。方法 采用微盘比色法对 67例头颈部恶性肿瘤 ,5 0例良性病变 ,40例健康人血清一氧化氮水平进行了检测。结果 ①恶性肿瘤组血清一氧化氮水平明显高于良性病变组和健康对照组 (P <0 .0 1)。②恶性肿瘤组术后 2周血清一氧化氮水平明显低于术前 (P <0 .0 1)。③颈淋巴结转移组明显高于非转移组 (P <0 .0 1)。结论 头颈部恶性肿瘤的发生与发展可能与血中一氧化氮水平升高有关。一氧化氮的检测对探讨肿瘤的发生机理、病情判断及指导治疗有一定价值。
Objective To investigate the significance of serum nitric oxide level in patients with head and neck malignant tumor before and after operation. Methods The level of serum nitric oxide in 67 cases of head and neck malignant tumor, 50 benign lesions and 40 healthy people were detected by microtiter plate colorimetry. Results ① The level of serum nitric oxide in malignant tumor group was significantly higher than that in benign disease group and healthy control group (P <0.01). ② The level of serum nitric oxide in malignant tumor group two weeks after operation was significantly lower than that before operation (P <0.01). ③ cervical lymph node metastasis was significantly higher than non-metastasis group (P <0.01). Conclusion The occurrence and development of head and neck malignant tumors may be related to the increase of blood nitric oxide level. Detection of nitric oxide to explore the pathogenesis of cancer, disease judgment and guidance and treatment of some value.