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舒马普坦（ｓｕｍａｔｒｉｐｔａｎ）的临床应用标志着偏头痛治 疗新世纪的开始，它与对５－ＨＴ机制研究的进展相一致。８０年代发明了５－ＨＴ 拮抗剂类止吐药，并研究了５－ＨＴ在抑郁和精神病方面的作用。其后对５－ＨＴ受体作用部位的研究加深了对受体功能的了解。５－Ｈ
The clinical application of sumatriptan marks the beginning of a new century of migraine treatment that is consistent with the progress made in the study of 5-HT mechanisms. In the 1980s, 5-HT antagonist antiemetics were invented and the role of 5-HT in depression and psychosis was studied. Subsequent studies of the site of 5-HT receptors have deepened the understanding of receptor function. 5-H