肿瘤免疫抵抗是原发性脑肿瘤的特征之一。美国每年新发脑肿瘤患者达到2万人,其中多形性神经胶质瘤是一种来源于神经胶质细胞的恶性肿瘤,其恶性程度极高,传统治疗手段疗效差,5年存活率小于2%。新近临床上倾向于使用实验性免疫治疗手段尝试治疗,因此探讨肿瘤免疫抵抗及逃逸机制有 Tumor immune resistance is one of the characteristics of primary brain tumors. The United States every year, new brain tumors reached 20,000 people, of which pleomorphic glioma is a malignant tumor derived from glial cells, the high degree of malignancy, the traditional treatment of poor efficacy, 5-year survival rate less than 2%. Recently, clinical trials tend to use experimental immunotherapy methods to try treatment, so to explore the tumor immune resistance and escape mechanism