对异氰酸盐过敏是造成多数工业职业性哮喘的原因,但迄今尚未见有家庭采用市售聚氨酯泡沫引起支气管痉挛的其它报告。一位38岁男性,于8年前在燃烧聚氨酯包装材料后发生支气管痉挛。经变换工种,呼吸道症状即消失,但患者最近主诉,在用聚氨酯泡沫给住宅窗户安隔热装置时,立即发生哮喘反应,24 h后出现面部肿胀、红疹,发病后4个月,实验室检查结果表明,嗜酸性粒细胞增多(7.14×10~8个/L),特异性异氰酸盐IgE浓度高[二异氰酸甲苯酯(TDI)和甲撑二苯基二异氰酸酯(MD1)为6 U,正常范围<2]。用常见吸入的过敏原作皮肤划痕试验为阴性,但用泡沫和MDI作 Allergy to isocyanates is the cause of most industrial occupational asthma, but so far no other reports of family use of commercially available polyurethane foam to cause bronchospasm have been reported. A 38-year-old man developed bronchospasm eight years after burning polyurethane packaging. Respiratory symptoms disappear after a change of job, but patients recently complained of an asthmatic response to polyurethane insulation on residential windows. Facial swelling and rash occurred 24 hours later, and four months after the onset of the disease The test results showed that eosinophilia (7.14 × 10-8 cells / L) and high specific IgE concentration of isocyanate [TDI and MD1) 6 U, normal range <2]. The skin scratch test with common inhaled allergens was negative, but with foam and MDI