难治性癫痫（IE）约占癫痫患者总数的10％～20％，目前国内外因缺乏实验动物模型，其研究难以深入，故其发病机理不明，临床治疗效果欠佳。本研究旨在探索建立IE动物模型的方法并探讨IE的形成机制。本研究选择电点燃大鼠癫痛模型作为制作IE模型的基础模型。40只日龄50天～60天 Refractory epilepsy (IE) accounts for about 10% to 20% of the total number of patients with epilepsy. At present, due to the lack of experimental animal models both at home and abroad, its research is difficult to study in depth. Therefore, its pathogenesis is unknown and the clinical treatment effect is not good. The purpose of this study was to explore ways to establish animal models of IE and to explore the mechanism of IE formation. This study chose to electrically stimulate rat epilepsy model as the basis for the production of IE model. 40 days of age 50 days to 60 days