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目的探讨妊娠合并哮喘孕妇血清IgE水平与哮喘病情变化的关系。方法选择70例不同严重程度的妊娠合并哮喘孕妇,运用酶联免疫吸附法对其过敏原特异性IgE抗体进行检测。结果过敏原特异性IgE抗体的阳性率以屋尘和螨虫阳性率最高;各组妊娠合并哮喘孕妇总IgE抗体阳性结果与检出过敏原种类差异有显著性意义。结论妊娠合并哮喘孕妇哮喘发作的主要诱因是屋尘和户尘螨;其严重程度与血清总IgE水平的高低呈正相关;对多种抗原表现特异性IgE阳性者往往病情较重。
Objective To investigate the relationship between serum IgE levels and the changes of asthma in pregnant women with asthma. Methods Seventy pregnant women with different severity of pregnancy complicated with asthma were enrolled in the study. Their allergen-specific IgE antibodies were detected by enzyme-linked immunosorbent assay. Results The positive rate of allergen-specific IgE antibody was the highest in house dust and mites. The positive rate of total IgE antibody in pregnant women with asthma complicated by pregnancy was significantly different from the type of allergen detected. Conclusions The main causes of asthma attacks in pregnant women with asthma are house dust and house dust mites. The severity of serum asthma is positively correlated with the level of total serum IgE. Serious IgE patients with multiple antigen-specific IgEs are often in severe condition.