论文部分内容阅读
目的观察他克莫司对肾病综合征患者肾功能和细胞因子水平的影响。方法 80例肾病综合征患者,随机分为对照组和观察组,各40例。对照组给予常规对症治疗,观察组于对照组基础上应用他克莫司治疗,均治疗2个疗程,比较两组患者疗效,并测定两组患者肾功能、血脂相关指标和白细胞介素4(IL-4)、肿瘤坏死因子α(TNF-α)水平变化情况。结果观察组仅3例无效,总有效率为92.5%(37/40),优于对照组的72.5%(29/40)(P<0.05);治疗后,观察组血肌酐、尿素氮水平均低于对照组(P<0.05);两组患者甘油三酯(TG)、总胆固醇(TC)、IL-4、TNF-α较治疗前降低,并且低于对照组(P<0.05)。结论他克莫司可有效改善肾病综合征患者的肾功能显著改善,降低血脂水平,并且可通过调节炎症因子水平发挥治疗作用。
Objective To observe the effect of tacrolimus on renal function and cytokine levels in patients with nephrotic syndrome. Methods Eighty patients with nephrotic syndrome were randomly divided into control group and observation group, 40 cases in each group. The control group was given conventional symptomatic treatment. The observation group was treated with tacrolimus on the basis of the control group. Both groups were treated with two courses of treatment. The curative effect of the two groups was compared. The renal function, serum lipid level and interleukin 4 IL-4) and tumor necrosis factor-α (TNF-α) levels. Results In the observation group, only 3 patients were ineffective and the total effective rate was 92.5% (37/40), which was better than that of the control group (72.5%, 29/40) (P <0.05). After the treatment, the serum creatinine and urea nitrogen (P <0.05). The triglyceride (TG), total cholesterol (TC), IL-4 and TNF-α in the two groups were lower than those before treatment and lower than those in the control group (P <0.05). Conclusion Tacrolimus can effectively improve the renal function in patients with nephrotic syndrome significantly improved, lower blood lipid levels, and can play a therapeutic role by regulating the level of inflammatory cytokines.