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目的了解阿里地区1~19岁人群HBsAg携带状况及抗-HBs水平,考评西藏阿里地区实施乙肝疫苗新生儿免费接种后的1~4岁人群免疫效果,以及接种对乙肝传播的阻断作用。方法全地区7个县共随机抽样1~19岁常住健康人群990人,检测HBsAg和抗-HBs。结果全地区1~19岁人群HBsAg携带率为13.84%,其男性阳性率为15.45%,女性阳性率为12.17%;抗-HBs阳性率为25.25%,其中男性阳性率为24.36%,女性阳性率为26.19%;1~4岁人群HBsAg携带率为7.14%,低于5~19岁人群HBsAg携带率15.07%;1~4岁人群抗-HBs阳性率为37.01%,5~19岁人群抗-HBs阳性率为22.97%。结论阿里地区1~19岁健康人群HBsAg携带率处于较高水平,1~4岁人群抗-HBs阳性率高于5~19岁人群,实施乙肝疫苗新生儿免费接种对乙肝传播有明显阻断作用。
Objective To understand the status of HBsAg carrier and anti-HBs in people aged 1-19 years in Ali Prefecture and to evaluate the immunization effect of newborns from 1 to 4 years old in Ali area of Tibet and the blocking effect of hepatitis B virus infection after vaccination. Methods A total of 990 healthy population from 19 to 19 years of age in seven counties in the region were randomly selected to detect HBsAg and anti-HBs. Results The overall prevalence of HBsAg was 13.84% in the population aged from 1 to 19 years. The positive rate was 15.45% in male and 12.17% in female. The positive rate of anti-HBs was 25.25%, and the positive rate was 24.36% , The prevalence of HBsAg was 7.14% in people aged 1-4, and the rate of HBsAg was 15.07% in those aged 5-19 years. The positive rate of anti-HBs was 37.01% in people aged 1-4, The positive rate of HBs was 22.97%. Conclusions HBsAg carrier rate in healthy population aged from 1 to 19 years in Ali area is relatively high. The positive rate of anti-HBs in 1 ~ 4 years old group is higher than that in 5 ~ 19 years old group. Free vaccination of newborn with Hepatitis B vaccine has a significant blocking effect on HBV transmission .