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目的探讨Merkel细胞癌的诊断、治疗及预后。方法对本科诊治的1例Merkel细胞癌病例进行光镜和免疫组化观察,并结合文献进行分析。结果瘤细胞核分裂像多,瘤细胞呈弥漫分布或巢索状排列。免疫组化标记显示:CK,Syn和cgA阳性。术后1周时发现有局部淋巴结转移。结论 Merkel细胞癌是一种较为罕见、且进展极快的皮肤肿瘤。诊断主要依靠组织病理,包括免疫组化方法,予以综合治疗后仍有局部复发和远处转移的倾向,预后较差。
Objective To investigate the diagnosis, treatment and prognosis of Merkel cell carcinoma. Methods A case of Merkel cell carcinoma diagnosed undergraduate was observed by light microscopy and immunohistochemistry, and analyzed by literature. Results as many as mitotic tumor cells, tumor cells were diffuse distribution or nest cord-like arrangement. Immunohistochemical markers showed: CK, Syn and cgA positive. Local lymph node metastasis was found at 1 week after operation. Conclusion Merkel cell carcinoma is a rare and rapidly progressing skin tumor. The diagnosis depends mainly on histopathology, including immunohistochemical methods, there is still a tendency of local recurrence and distant metastasis after comprehensive treatment, the prognosis is poor.