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目的:对不同产地洋金花中东莨菪碱及其他特征成分的含量进行比较分析,为药材选择和制剂质量控制提供参考。方法:采用高效液相色谱法,对色谱图进行分析,并以氢溴酸东莨菪碱为对照品,对各峰含量及百分率进行分析。结果:不同产地间洋金花中东莨菪碱的含量差异较大,海南的洋金花中东莨菪碱含量是广西的1.953倍;其他特征成分的含量也有较大差异,以5个特征成分的总和计算的百分比含量中,海南的洋金花是广西的1.687倍。结论:应用高效液相含量测定及指纹图谱的方法对有毒中药洋金花的质量进行控制是可行的。
OBJECTIVE: To compare and analyze the contents of scopolamine and other characteristic components in the flowers of Gentiana macrophylla from different habitats, and provide a reference for the selection of herbs and the quality control of preparations. Methods: The chromatograms were analyzed by high performance liquid chromatography (HPLC). Scopolamine hydrobromide was used as reference substance to analyze the content and percentage of each peak. Results: The content of scopolamine in the different regions of Jinhuahua was quite different. The content of scopolamine in Hainan camellia was 1.953 times that of Guangxi. The contents of other features were also different. The percentage calculated by the sum of the five characteristic components Content, Hainan Yang Jinhua is 1.687 times that of Guangxi. Conclusion: It is feasible to control the quality of the poisonous Chinese medicinal flower by high performance liquid chromatography and fingerprinting.