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报告120例Graves 病(GD)和30例桥本氏甲状腺炎(HT)患者甲状腺自身抗体和淋巴细胞亚群的实验结果。GD 未治组TRAb、TMA 和TGA 阳性率分别为88.9%、61.1%和57.8%;HT 未治组阳性率分别为20.0%.80.0%和70.0%。GD 和HT 未治组CD_3~+、CD_(?)~+明显下降,CD_4~+/CD_(?)~+比值和CD_(20)~+显著上升(P<0.01)。GD 缓解组以上各指标恢复正常。GD 未治组TRAb 含量与CD_(8)~+的负相关性强于TRAb 与CD_(20)~+的正相关性。提示CD_8~+和TRAb 的测定是确定Graves 病及其治疗效果和预后的重要指标。
The results of thyroid autoantibodies and lymphocyte subsets in 120 Graves disease (GD) and 30 Hashimoto’s thyroiditis (HT) patients were reported. The positive rates of TRAb, TMA and TGA in GD non-treatment group were 88.9%, 61.1% and 57.8% respectively; the positive rates of HT in untreated group were 20.0%, 80.0% and 70.0% respectively. CD_3 ~ + and CD_ (~) ~ + in GD and HT groups were significantly decreased, and CD_4 ~ + / CD_ (~) ~ + ratio and CD_ (20) ~ + increased significantly (P <0.01). GD remission group of the above indicators returned to normal. The negative correlation between TRAb and CD_ (8) ~ + in GD group was stronger than that between TRAb and CD_ (20) ~ +. It is suggested that the determination of CD_8 ~ + and TRAb is an important index for determining Graves’ disease and its therapeutic effect and prognosis.