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目的:研究在不同温度(4℃,25℃,37℃)条件下头孢哌酮钠和利巴韦林注射液在0.9％氯化钠注射液,葡萄糖氯化钠注射液,10％葡萄糖注射液3种输液中的配伍稳定性。方法:将头孢哌酮钠,利巴韦林注射液加入3种不同的输液中,配成浓度分别为2mg·ml~(-1),1mg·ml~(-1)的混合液,放置不同温度下(4℃,25℃,37℃),用紫外分光光度法,测定配伍后不同时间混合液中两药的浓度,同时检查混合液pH值、外观及不溶性微粒变化。结果:二者混合液放置在4℃,8h,微粒数超过规定标准;放置在25℃,37℃下在8h内溶液均澄明,pH值、含量没有明显变化。结论:头孢哌酮钠和利巴韦林注射液在3种输液中配伍8h内稳定,在低温下,不溶性微粒有增多的可能。
Objective: To study the effects of cefoperazone sodium and ribavirin injection in 0.9% sodium chloride injection, glucose and sodium chloride injection and 10% glucose injection under different temperatures (4 ℃, 25 ℃, 37 ℃) In the compatibility of stability. Methods: The cefoperazone sodium and ribavirin injection were added into three different infusion solutions to prepare a mixture of 2 mg · ml -1 and 1 mg · ml -1, respectively, and placed at different temperatures ( 4 ℃, 25 ℃, 37 ℃). The concentration of the two drugs in the mixed solution was determined by UV spectrophotometry at the same time. The pH value, appearance and the changes of the insoluble particles in the mixed solution were also examined. Results: The mixture of the two solutions was placed at 4 ° C for 8h, the number of particles exceeded the required standard. The solution was clear at pH 8 and 37 ℃ for 8 hours. The pH value and content did not change significantly. CONCLUSION: Cefoperazone sodium and ribavirin injection are stable within 8 h in 3 kinds of infusions, and the insoluble particulates may increase at low temperature.