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Objective: To compare the pharmacokinetics of the routine intraperitoneal chemotherapy (RIP) and continuous washing intraperitoneal chemotherapy (CWIP) of cisplatin (CDDP) in 38 patients with ovarian cancer.Methods:The patients had a performance status of II -IV on the FIGO scale.38 patients were randomized into CWIP group (16 patients) and RIP group (22 patients). CDDP was used as intraperitoneal chemotherapy (IP) with 70mg/m2. In 72h, the samples from serum, ascites and urine were collected respectively and their platinum density were determined with electrochemistry polarographic analysis. On the third day and one month after IP, liver and kidney function and blood routine were examined. Results: The maximum concentration (Omax) of plasma in CWIP and RIP groups were 3.84μg/ml and 1.27μg/ml respectively; the Cmax of ascites were 7.04μg/ml and 4.43μg/ml respectively in the two groups.The area under the plasma concentration-time curve(AUC) in CWIP and RIP groups were 1067.77μg/ml and 191. 72μg.h/m
Objective: To compare the pharmacokinetics of the routine intraperitoneal chemotherapy (RIP) and continuous washing intraperitoneal chemotherapy (CWIP) of cisplatin (CDDP) in 38 patients with ovarian cancer. Methods: The patients had a performance status of II-IV on the FIGO scale .38 patients were randomized into CWIP group (16 patients) and RIP group (22 patients). CDDP was used as intraperitoneal chemotherapy (IP) with 70 mg / m2. In 72h, the samples from serum, ascites and urine were collected respectively and their On the third day and one month after IP, liver and kidney function and blood routine were examined. Results: The maximum concentration (Omax) of plasma in CWIP and RIP groups were 3.84 μg / ml and 1.27 μg / ml respectively; the Cmax of ascites were 7.04 μg / ml and 4.43 μg / ml respectively in the two groups. Area under the plasma concentration-time curve (AUC) in CWIP and RIP groups were 1067.77 μg / ml and 191. 72 μg.h / m