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应用国产磷酸咯萘啶治疗非洲桑给巴尔籍140例恶性反复发作性疟疾,应用4mg/kg 体重深部肌肉注射,6小时后复注一次。若48小时后疟原虫不转阴者再给药一次。观察退热时间及疟原虫转阴时间均显著短于30例应用氯喹治疗的对照组(P<0.001)。且对氯喹耐药虫株同样有效。治疗期间作用药前后ECG,肝功能及尿常规检查说明本品杀虫作用强、副作用少。
Application of domestic production of pyronaridine phosphate treatment of African Zanzibar 140 cases of recurrent malaria, the application of 4mg / kg body weight deep intramuscular injection, 6 hours after the re-injection. If 48 hours after the malaria parasite is not negative again dosing. The duration of fever and the negative conversion of malaria parasites were significantly shorter than those in the control group treated with chloroquine (P <0.001). And chloroquine resistant strains equally effective. Before and after treatment during the treatment of ECG, liver function and urine tests show that this product insecticidal effect, less side effects.